The basic structure would be
1) Open up XL using DDT and read information(sheet 1) to variables what you have to run (One instance of TC can not open up several excel sheet at a given time)DDT drive
2) Run your test running test
3) End of each test record your results handling results
following links may also help...
As you have understand this would be bit complex even for a experienced guy. Hence my advice is just start with what ever you have or you can. On the progress we (forum) can help with exact technical problems.
P.S.
By the way why don't you use existing functionality of TC for do the same thing Eg Test_Items and TC Logs ?
